Day returns as Saints square up to Gloucester
The lock has been sidelined with a ruptured bicep during the formative stages of the campaign, but returned to play 40 minutes for the Wanderers on Monday night.
And he will now come straight back into the team, taking the place of Michael Paterson, with Saints making five changes to the team that was thrashed 41-7 at Castres last Saturday.
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Hide AdMike Haywood replaces Dylan Hartley, who is on the bench, while Calum Clark, who was rested last weekend, replaces Teimana Harrison.
Lee Dickson comes in for Nic Groom, while George Pisi is also back, replacing Rory Hutchinson at outside centre.
Saints have won just two of their Aviva Premiership matches so far, losing four times, while Gloucester have only claimed one league victory this season.
Saints: Foden; Wilson, G Pisi, Mallinder, North; Myler, Dickson; A Waller, Haywood, Brookes; Lawes, Day; Wood (c), Clark, Picamoles.
Replacements: Hartley, E Waller, Hill, Paterson, Gibson, Kessell, Tuala, Hutchinson.